Search results for "Farmàcia Investigació"
showing 3 items of 3 documents
Complete blockade of the vasorelaxant effects of Ang-(1-7) and bradykinin in murine microvessels by antagonists of the receptor Mas.
2013
The heptapeptide angiotensin-(1-7) is a biologically active metabolite of angiotensin II, the predominant peptide of the renin-angiotensin system. Recently, we have shown that the receptor Mas is associated with angiotensin-(1-7)-induced signalling and mediates, at least in part, the vasodilatory properties of angiotensin-(1-7). However, it remained controversial whether an additional receptor could account for angiotensin-(1-7)-induced vasorelaxation. Here, we used two different angiotensin-(1-7) antagonists, A779 and d-Pro-angiotensin-(1-7), to address this question and also to study their influence on the vasodilatation induced by bradykinin. Isolated mesenteric microvessels from both wi…
Última lección de cátedra de Román Casares López (UCM, 1978)
2022
Este trabajo consiste en la transcripción y contextualización de la última lección de cátedra de Román Casares López (1908-1990), catedrático de análisis químico en la Facultad de Farmacia de Madrid. Se trata de una conferencia impartida el 6 de mayo de 1978, registrada en un casete con una duración de 51 minutos y 25 segundos donado al Archivo General de la Universidad Complutense de Madrid y digitalizado recientemente. Esta fuente histórica, situada entre el contexto docente y una historia de vida, ofrece detalles de gran interés tanto sobre su autor, como sobre la farmacia y la química de la España franquista.
Genotype-driven pharmacokinetic simulations of warfarin levels in Puerto Ricans.
2020
Abstract Objectives The inter-individual variability of warfarin dosing has been linked to genetic polymorphisms. This study was aimed at performing genotype-driven pharmacokinetic (PK) simulations to predict warfarin levels in Puerto Ricans. Methods Analysis of each individual dataset was performed by one-compartmental modeling using WinNonlin®v6.4. The k e of warfarin given a cytochrome P450 2C9 (CYP2C9) genotype ranged from 0.0189 to 0.0075 h−1. K a and V d parameters were taken from literature. Data from 128 subjects were divided into two groups (i.e., wild-types and carriers) and statistical analyses of PK parameters were performed by unpaired t-tests. Results In the carrier group (n=6…